|
|
|
|
|
| Available: 0 |
| List Price:$249.99 |
|
Other formats:
|
| Edition: | 1st |
| Publisher: | Springer Nature |
| ISBN: | 981-1376-46-8 (9811376468) |
| ISBN-13: | 978-981-1376-46-7 (9789811376467) |
| Binding: | Hardcover |
| Copyright: | 2019 |
| Publish Date: | 10/19 |
| Volume: | 1141 |
| Weight: | 2.10 Lbs. |
| Pages: | 580 |
| Subject Class: | PRM (Pharmacology) |
| Return Policy: | Returns accepted up to 12 months provided no other recalls or return restrictions apply. |
| Contributing Authors: |
View
|
| ProQuest Ebook Central: |
Available in ProQuest Ebook Central™ View
|
|
|
| |
| ISSN Series: | Advances in Experimental Medicine & Biology | | Discipline: | Pharmacology | | Subject Definition: | Drug Carriers | | NLM Class: | QV 785 | | LC Class: | RS201 | | Abstract: | This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and theirgene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presents a number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions.This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field. |
|
|
|
|
|
|
Follow Matthews Book Co. on:
Copyright © 2001-2024 Matthews Book Company - All rights reserved. - 11559 Rock Island Ct., Maryland Heights, MO, 63043 - (800) MED-BOOK
Matthews