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Acute Neuronal Injury
Fujikawa, Denson G. MD
Pricing & Availability
Available: Yes*
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Book Information
Edition:
1st
Publisher:
Springer Nature
ISBN:
0-387-73226-8 (0387732268)
ISBN-13:
978-0-387-73226-8 (9780387732268)
Binding:
E E Book + ProQuest Ebook Central
Copyright:
2010
Publish Date:
12/08
Weight:
0.00 Lbs.
Subject Class:
RET (Returns)
Remarks:
A New Edition of this Title is Available
Return Policy:
Non-Returnable.
Table Of Contents:
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Class Specifications
Discipline:
Nervous Sys
Subject Definition:
Neurons; Cell Cycle; Apoptosis
NLM Class:
WL 102.5
LC Class:
RC365
Abstract:
This book is the result of a convergence of scientific information regarding mechanisms that produce acute nerve cell death in the brain. Although seemingly disparate, stroke, brain and spinal cord trauma, coma from a low serum glucose concentration (hypoglycemia), and prolonged epileptic seizures have in common the inciting factor of excitotoxicity, the activation of a specific subtype of glutamate receptor by an elevated extracellular glutamate concentration that results in an excessive influx of calcium into nerve cells. The high calcium concentration in nerve cells activates several enzymes that are responsible for degradation of cytoplasmic proteins and cleavage of nuclear DNA, resulting in nerve cell death. The high calcium concentration also interferes with mitochondrial respiration, with the resultant production of free radicals that damage cellular membranes and nuclear DNA. Understanding the biochemical pathways that produce nerve cell death is the first step toward devising an effective neuroprotective strategy, the ultimate goal. Acute Neuronal Injury will be useful to neuroscientists and general cell biologists interested in cell death. The book will also be helpful to clinically oriented neuroscientists, including neurologists, neurosurgeons and psychiatrists.
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