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Neuroendocrine Cells and Peptidergic Innervation in Human and Rat Prostate
Santamaria, Luis
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Book Information
Edition:
1st
Publisher:
Springer Nature
ISBN:
3-540-69816-7 (3540698167)
ISBN-13:
978-3-540-69816-6 (9783540698166)
Binding:
E E Book + ProQuest Ebook Central
Copyright:
2007
Publish Date:
07/07
Volume:
194
Weight:
0.00 Lbs.
Subject Class:
URL (Urology)
Return Policy:
Non-Returnable.
Table Of Contents:
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Class Specifications
ISSN Series:
Advances in Anatomy, Embryology, and Cell Biology
Discipline:
Urogenital Sys
Subject Definition:
Prostate-Cytology; Prostate-Innervation
NLM Class:
WJ 750
LC Class:
RC899
Abstract:
The prostate hosts an important amount of neuroendocrine cells which origin and functional role need to be better addressed. These cells synthesize and deliver a number of neurosecretory substances (serotonin, neuropeptides) having regulative activities over growth, cell differentiation, and secretion and might have a remarkable influence in the development of prostatic proliferative disorders such as hyperplasia or cancer. Using immunohistochemistry and stereologic quantification, the authors of the present study deal with the demonstration that the neuroendocrine cells population from transition zone of the human prostate was greater than in both central and peripheral regions, and this can be put in relation to the genesis of BPH. Furthermore, they observed that the neuroendocrine cells and the peptidergic innervation of rat prostate might be influenced by aging and androgenic status. Other factors, as pharmacological castration, or prolactin action, might be also modulate the neuroendocrine-peptidergic system.
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