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Product Detail
Cell Death: Apoptosis and Other Means to an End
Green, Douglas R.
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List Price:$81.00
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Book Information
Edition:
2nd
Publisher:
Cold Spring Harbor Laboratory
ISBN:
1-62182-213-3 (1621822133)
ISBN-13:
978-1-62182-213-4 (9781621822134)
Binding:
Hardcover
Copyright:
2018
Publish Date:
10/18
Weight:
1.70 Lbs.
Pages:
278
Subject Class:
ONC (Oncology)
Return Policy:
Returns accepted up to 90 days provided no other recalls or return restrictions apply.
Contributing Authors:
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Class Specifications
Discipline:
Biochemistry
Subject Definition:
Cell Death
NLM Class:
QU 25
LC Class:
QH671
Abstract:
One million cells in our bodies die every second--they commit suicide by a mechanism known as apoptosis. Apoptosis is essential for survival of the body as a whole and has critical roles in various developmental processes and the immune system. In Cell Death, Douglas Green provides a clear and comprehensive view of apoptosis and other cell death mechanisms. Taking a bottom-up approach, he starts with the enzymes that perform the execution process (a family of proteases termed caspases) and examines their cellular targets and the ways in which they are activated. He then looks at the molecular machinery that links signals that cause cell death to caspases, emphasizing the importance of the BCL-2 family of proteins and the role of cytochrome c released from mitochondria. The final stage of the process, phagocytic removal of dead or dying cells, is also covered. Green outlines the roles of apoptosis and death mechanisms such as necrosis in embryogenesis, neuronal selection, and the development of self-tolerance in the immune system. In addition, he explains how cell death defends the body against cancer and traces the evolutionary origins of the apoptosis machinery back over a billion years. This new edition contains critical new information on recent exciting advances in the field, such as new forms for cell death and important insights into the mechanisms and control of apoptosis. The book is thus of great use to all biologists interested in how cells function in the context of multicellular organisms and will appeal to everyone from undergraduates encountering the topic for the first time to researchers actively working in the field.
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