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ebc item NOTICE: This is the ProQuest Ebook Central™ format of this title. What is ProQuest Ebook Central™?
Other formats: Hardcover All Formats

Drug Transporters in Drug Disposition, Effects and Toxicity

Liu, X
Drug Transporters in Drug Disposition, Effects and Toxicity Cover Image
Pricing & Availability
Available: Yes*
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Book Information
Edition: 1st
Publisher: Springer
ISBN: 981-1376-47-6 (9811376476)
ISBN-13: 978-981-1376-47-4 (9789811376474)
Binding: E E Book + ProQuest Ebook Central
Copyright: 2019
Publish Date: 10/19
Volume: 1141
Weight: 0.00 Lbs.
Subject Class: PRM (Pharmacology)
Return Policy: Non-Returnable.
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Class Specifications
ISSN Series: Advances in Experimental Medicine & Biology
Discipline: Pharmacology
Subject Definition: Drug Carriers
NLM Class: QV 785
LC Class: RS201
Abstract: This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and theirgene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presents a number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions.This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.
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