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Antimicrobial Peptides: Basics for Clinical Application

Matsuzaki, Katsumi
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Book Information
Edition: 1st
Publisher: Springer Nature
ISBN: 981-1335-87-7 (9811335877)
ISBN-13: 978-981-1335-87-7 (9789811335877)
Binding: Hardcover
Copyright: 2019
Publish Date: 05/19
Volume: 1117
Weight: 1.64 Lbs.
Pages: 304
Subject Class: PRM (Pharmacology)
Return Policy: Returns accepted up to 12 months provided no other recalls or return restrictions apply.
Contributing Authors: View
 
Class Specifications
ISSN Series: Advances in Experimental Medicine & Biology
Discipline: Biochemistry
Subject Definition: Peptides-Therapeutic Use; Anti-Infect Agents
NLM Class: QU 68
LC Class: RS431
Abstract: This book presents an overview of antimicrobial peptides (AMPs), their mechanisms of antimicrobial action, other activities, and various problems that must still be overcome regarding their clinical application. Divided into four major parts, the book begins with a general overview of AMPs (Part I), and subsequently discusses the various mechanisms of antimicrobial action and methods for researching them (Part 2). It then addresses a range of activities other than antimicrobial action, such as cell penetration, antisepsis, anticancer, and immunomodulatory activities (Part 3), and explores the prospects of clinical application from various standpoints such as the selective toxicity, design, and discovery of AMPs (Part 4). A huge number of AMPs have been discovered in plants, insects, and vertebrates including humans, and constitute host defense systems against invading pathogenic microorganisms. Consequently, many attempts have been made to utilize AMPs as antibiotics. AMPs could help to solve the urgent problem of drug-resistant bacteria, and are also promising with regard to sepsis and cancer therapy. Gathering a wealth of information, this book will be a bible for all those seeking to develop antibiotics, anti-sepsis, or anticancer agents based on AMPs.
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