Product Detail
Cytokine Storm Syndrome
Cron, Randy Q.
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Book Information
Edition:
2nd
Publisher:
Springer Nature
ISBN:
3-031-59814-8 (3031598148)
ISBN-13:
978-3-031-59814-2 (9783031598142)
Old Edition:
3-030-22093-1
Format:
Textbook
Binding:
Hardcover
Copyright:
2024
Publish Date:
08/24
Volume:
1448
Weight:
2.89 Lbs.
Pages:
628
Subject Class:
AIM (Allergy and Immunology)
Return Policy:
Returns accepted up to 12 months provided no other recalls or return restrictions apply.
Contributing Authors:
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Class Specifications
ISSN Series:
Advances in Experimental Medicine & Biology
Discipline:
Micro/Immuno
Subject Definition:
Cytokines; Imuune System Diseases
NLM Class:
QW 504
LC Class:
RC582
Abstract:
Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals. A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This second edition addresses all aspects of the disorder, from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors and treatment. New-to-this-edition features include dedicated chapters on severe COVID-19 CSS, and post-COVID CSS of multi-system inflammatory syndrome in children (MIS-C). In addition, novel topics including CSS associated with Castleman disease, pregnancy, therapeutics, transplantation, and cardiac bypass, as well as treatment with JAK inhibitors are addressed.
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