Site Specific and Global Epigenomic Editing:Principles and Applications

Zhou, Feng C

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Book Information
Edition:	1st
Publisher:	Academic Press, Incorporated
ISBN:	0-12-819398-0 (0128193980)
ISBN-13:	978-0-12-819398-3 (9780128193983)
Binding:	Softcover
Copyright:	2022
Volume:	33
Weight:	0.00 Lbs.
Pages:	704
Subject Class:	GEN (Genetics)
Remarks:	This Title is Not Yet Published, Scheduled to Release 06/01/24
Return Policy:	Returns accepted up to 90 days provided no other recalls or return restrictions apply.

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Abstract:

In recent years, alongside the largely popularized advances in human genome editing and CRISPR-cas9-driven therapeutics, epigenomic editing has made strong strides, though a clear understanding is still forming in the field of the exact role that epigenetics play in pathogenesis, the full range of sites for possible epigenetic modification, and the potential to target these sites to modulate disease progression. Key questions for researchers embarking in this field include: Which of the hundreds of epigenomic marks and features are relevant, and which of those are likely to serve a role in regulating gene expression, cell behavior, and phenotypic outcomes? This volume is the first to provide a thorough, conceptual introduction to the field of epigenetic regulation and a thorough accounting of sites for possible epigenetic edits and disease modulation. Protocols, and applied case studies examine early disease targets and likely pathways of therapeutic significance, while also outlining common challenges in the field, and the addressing the range of bioethical questions that come with altering phenotypes. This book addresses its topic in a comprehensive, but accessible manner, highlighting practical tools and burning questions remaining in the field to enable fresh research. Offers a full, conceptual and applied framework for implementing epigenomic editing in biological research and drug discovery Discusses fundamental theory, experimental design, and applied approaches alongside common research challenges and bioethical concerns Examines epigenomic editing's potential role in modulation of developmental, neuropsychiatric, and immunological disorders, as well as viral infections and cancer

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