Product Detail
NOTICE: This is the ProQuest Ebook Central� format of this title.
What is ProQuest Ebook Central�?
Other formats:
Hardcover
All Formats
B Cell Receptor Signaling
Kurosaki, Tomohiro
Pricing & Availability
Available: Yes*
This title does not qualify for any discount.
Other formats:
Hardcover
All Formats
Book Information
Edition:
1st
Publisher:
Springer Nature
ISBN:
3-319-26133-9 (3319261339)
ISBN-13:
978-3-319-26133-1 (9783319261331)
Binding:
E E Book + ProQuest Ebook Central
Copyright:
2016
Publish Date:
01/16
Volume:
393
Weight:
0.00 Lbs.
Carton Quantity:
30
Subject Class:
BCH (Biochemistry)
Return Policy:
Non-Returnable.
Table Of Contents:
View
ProQuest Ebook Central�:
Please sign in to preview this title
Class Specifications
ISSN Series:
Current Topics in Microbiology and Immunology
Discipline:
Micro/Immuno
Subject Definition:
Receptors, Antigen, B-Cell-Metabolism; Signal Transduction
NLM Class:
QW 573
LC Class:
QR185.8
Abstract:
This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton's Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.
* Subject to ProQuest Ebook Central� availability
close
Follow Matthews Book Co. on:
Copyright © 2001-2024 Matthews Book Company - All rights reserved. - 11559 Rock Island Ct., Maryland Heights, MO, 63043 - (800) MED-BOOK
Matthews
Privacy Statement