|
|
|
|
|
|
| Available: Yes* |
| This title does not qualify for any discount. |
|
Other formats:
|
| Edition: | 1st |
| Publisher: | Springer Nature |
| ISBN: | 3-540-31209-9 (3540312099) |
| ISBN-13: | 978-3-540-31209-3 (9783540312093) |
| Binding: | E E Book + ProQuest Ebook Central |
| Copyright: | 2007 |
| Publish Date: | 07/07 |
| Volume: | 172 |
| Weight: | 0.00 Lbs. |
| Subject Class: | ONC (Oncology) |
| Return Policy: | Non-Returnable. |
| Table Of Contents: |
View
|
| |
|
| ProQuest Ebook Central�: |
Please sign in to preview this title
|
|
|
| |
| ISSN Series: | Recent Results in Cancer Research | | Discipline: | Pathology | | Subject Definition: | Neoplasms-Therapy; Neoplasms-Drug Therapy | | NLM Class: | QZ 267 | | LC Class: | RC271 | | Abstract: | Two aspects of biological research are major contributors to the progress in the understanding of cancer etiology and the development of new and improved cancer drugs. The sequencing of the human genome provides us with a basic overview of all our genes and gene products, and the insights into signaling pathways allow us to align crucial components of cellular regulation into an ordered functional context. A comparison of the genes in normal and in tumor cells shows that mutations in the DNA of a limited set of genes are responsible for the multiple stages of tumorigenesis and metastasis. Many of the affected genes, including oncogenes, tumor suppressor genes and genome stability genes, can be fitted into pathways. They encode molecules that stimulate tumor cell division or inhibit their death. Matching of therapeutic intervention with insights into the underlying molecular disease mechanism has already led to the development of drugs such as Herceptin and Glivec. The deregulation of pathways as a consequence of the altered biochemical function of mutated cancer genes provides the conceptual basis for future progress. Our ability to predict the consequences of inhibition of such components, however, is still limited. For this reason, the development of targeted drugs remains a complex process, comprising rational and empirical elements. The state of development of tomorrow.s cancer drugs, directed against growth factors, growth factor receptors and intracellular signaling molecules with kinase activities, is described in this book. |
|
|
* Subject to ProQuest Ebook Central� availability |
|
|
|
|
|
|
|
Follow Matthews Book Co. on:
Copyright © 2001-2024 Matthews Book Company - All rights reserved. - 11559 Rock Island Ct., Maryland Heights, MO, 63043 - (800) MED-BOOK
Matthews