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Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery
Miller, S
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Available: Yes*
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Book Information
Edition:
1st
Publisher:
Wiley-Blackwell
ISBN:
3-527-69411-0 (3527694110)
ISBN-13:
978-3-527-69411-2 (9783527694112)
Binding:
E E Book + ProQuest Ebook Central
Copyright:
2016
Publish Date:
10/16
Volume:
7
Weight:
0.00 Lbs.
Carton Quantity:
8
Subject Class:
RET (Returns)
Return Policy:
Non-Returnable.
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Class Specifications
Discipline:
Parasitology
Subject Definition:
Parasites-Metabolism; Research; Drug Discovery; Metabolomics
NLM Class:
QX 20
LC Class:
RC119
Abstract:
Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art omics technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented.
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