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Companion and Complementary Diagnostics: From Biomarker Discovery to Clinical Implementation

Jorgensen, Jan T

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Book Information
Edition:	1st
Publisher:	Academic Press, Incorporated
ISBN:	0-12-813540-9 (0128135409)
ISBN-13:	978-0-12-813540-2 (9780128135402)
Binding:	E E Book + ProQuest Ebook Central
Copyright:	2019
Publish Date:	05/19
Weight:	0.00 Lbs.
Subject Class:	PRM (Pharmacology)
Return Policy:	Non-Returnable.

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Class Specifications
Discipline:	Pharmacology
Subject Definition:	Biomarkers, Pharmacological; Holistic Health
NLM Class:	QV 744
LC Class:	R853
Abstract:	Companion and Complementary Diagnostics: From Biomarkers to Diagnostics provides the reader with an in-depth insight into the individual steps in the development of companion diagnostic assays, from the early biomarker discovery phase over analytical and clinical validation to the final regulatory approval. Further, the clinical implementation of companion diagnostic testing in the clinic will be discussed in the book. Within the last decade, we have seen an increasing number of predictive biomarker assays being developed using the drug-diagnostic co-development model. For a number of targeted oncology drugs companion diagnostic assays have taken up a central role in the development process, and the success of this type of therapy largely depends on their performance. The companion diagnostic assays have the individual patient as a point of reference and they will be decisive for the move toward a more individualized pharmacotherapy and are seen as an important element in the realization of precision medicine. The development of predictive or selective biomarker assays linked to specific drugs will increase substantial in the years to come, and this book offers comprehensive information that covers this fast evolving area of biomedicine. Diagnostics is an essential resource for those who work at academic institutions, hospitals and pharma, biotech and diagnostic commercial companies.

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