Subthalamic Nucleus Part II: Modelling and Simulation of Activity

Heida, Tjitske

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Book Information
Edition:	1st
Publisher:	Springer Nature
ISBN:	3-540-79461-1 (3540794611)
ISBN-13:	978-3-540-79461-5 (9783540794615)
Binding:	Softcover
Copyright:	2008
Publish Date:	09/08
Volume:	199
Weight:	0.50 Lbs.
Pages:	88
Subject Class:	ANT (Anatomy and Embryology)
Remarks:	Print on Demand. Please allow additional time for delivery.
Return Policy:	Returns accepted up to 12 months provided no other recalls or return restrictions apply.
Table Of Contents:	View
Contributing Authors:	View
ProQuest Ebook Central:	Available in ProQuest Ebook Central™ View

Class Specifications
ISSN Series:	Advances in Anatomy, Embryology, and Cell Biology
Discipline:	Nervous Sys
Subject Definition:	Subthalamic Nucleus
NLM Class:	WL 100
LC Class:	QP383.7
Abstract:	Part II starts with a systemic model of the basal ganglia to evaluate the position of the STN in the direct, indirect and hyperdirect pathways. A summary of in vitro studies is given, describing STN spontaneous activity as well as responses to depolarizing and hyperpolarizing inputs, and high frequency stimulation. STN bursting activity and the underlying ionic mechanisms are investigated. Deep brain stimulation used for symptomatic treatment of Parkinson's disease is discussed in terms of the elements that are influenced and its hypothesized mechanisms. This part of the monograph pays attention to the pedunculopontine-subthalamic connections and tries in cell cultures to mimic neurotransmitter actions of the pedunculopontine nucleus and high frequency stimulation on cultured dissociated rat subthalamic neurons. STN cell models: single and multi compartment, and system level models are discussed in relation to subthalamic function and dysfunction. Part I and II are mutually compared.